Zollinger-Ellison syndrome is associated with which genetic condition?

Zollinger-Ellison syndrome is primarily associated with MEN 1 syndrome, also known as Wermer's syndrome. This condition is characterized by the presence of gastrin-secreting tumors known as gastrinomas, which lead to excessive gastric acid production and recurrent peptic ulcers. MEN 1 syndrome is a genetic disorder caused by mutations in the MEN1 gene, which predisposes individuals to a triad of endocrine tumors, including those of the pancreas (such as gastrinomas), the parathyroid glands, and the pituitary gland.

The link between Zollinger-Ellison syndrome and MEN 1 syndrome is significant because patients with MEN 1 often develop gastrinomas as part of their clinical presentation. This association highlights the importance of recognizing this genetic condition when diagnosing and managing patients with Zollinger-Ellison syndrome, as targeted surveillance and treatment strategies can be implemented for individuals with MEN 1.

The other listed conditions do not have a direct association with Zollinger-Ellison syndrome. For instance, MEN 2A syndrome is related to medullary thyroid carcinoma and pheochromocytoma and is not typically linked with gastrin-secreting tumors. Marfan syndrome and Turner syndrome are genetic conditions with their specific clinical features