Which syndrome is characterized by situs inversus, chronic sinusitis, and bronchiectasis?

The condition characterized by situs inversus, chronic sinusitis, and bronchiectasis is known as Kartagener's syndrome. This syndrome is a type of primary ciliary dyskinesia, where the cilia, which are tiny hair-like structures that line the respiratory tract and play a crucial role in clearing mucus and pathogens, are immobile or have impaired motility. This impaired ciliary function leads to the accumulation of mucus and an increased susceptibility to infections, resulting in chronic sinusitis and bronchiectasis.

Situs inversus occurs due to the abnormal positioning of internal organs, which is a common finding in individuals with Kartagener's syndrome. The association of all three features—situs inversus, chronic sinusitis, and bronchiectasis—is a classic triad that aids in the diagnosis of this disorder. By understanding these connections, it becomes clear why this particular combination of symptoms points directly to Kartagener's syndrome compared to the other syndromes listed.