Which serologic marker is present in individuals vaccinated against Hepatitis B?

Individuals vaccinated against Hepatitis B will have the presence of anti-HB surface IgG in their serologic profile. This immunoglobulin is the result of the immune system generating an antibody response following vaccination with the Hepatitis B surface antigen (HBsAg).

The vaccine contains purified HBsAg that stimulates the body to produce antibodies without causing the disease. The presence of anti-HB surface IgG indicates that the individual has successfully developed immunity against Hepatitis B, providing protection from future infections.

In contrast, the HB surface antigen indicates an active Hepatitis B infection, while anti-HB core IgM typically appears during acute infections. HB e antigen is also associated with active viral replication and is not a marker for vaccination. Hence, the presence of anti-HB surface IgG is the hallmark of successful vaccination and immunity to Hepatitis B.