Which patient population is most prone to developing bullous pemphigoid?

Bullous pemphigoid is an autoimmune blistering disorder primarily seen in older adults. The condition arises when the body's immune system mistakenly attacks components of the skin, specifically the hemidesmosomes, leading to the formation of tense blisters, typically significant on the abdomen, groin, and extremities.

The most prevalent demographic affected by bullous pemphigoid are individuals over the age of 60, with the incidence increasing with age. The typical age range for new diagnoses often starts in the mid-60s or later. The pathophysiology involves IgG antibodies directed against the basement membrane zone, which plays a crucial role in the structural integrity of the skin. Because of both the immunosenescence associated with aging and the potential for increased antigen exposure over time, older adults represent the population at highest risk for developing this condition.

In contrast, young adults, children, and pregnant women have significantly lower incidences of bullous pemphigoid. Young adults may experience other skin disorders but are not a common demographic for this specific condition. Children under 10 are typically not affected, as the disease is primarily seen in the older population. Pregnant women can develop other types of pemphigoid gestationis, which is