Which of the following conditions is NOT typically associated with Wilson disease?

Wilson disease is a genetic disorder that leads to excessive copper accumulation in the body. The manifestations of Wilson disease can affect multiple organ systems, particularly the liver and the brain, but other presentations can occur as well.

Chronic obstructive pulmonary disease (COPD) is primarily associated with smoking and environmental factors that lead to airway obstruction and lung tissue damage. There is no direct link between COPD and Wilson disease. Unlike the other conditions listed, COPD does not arise as a consequence of copper metabolism or accumulation.

Coombs-negative hemolytic anemia, renal tubular acidosis (RTA), and nephrolithiasis (kidney stones) are conditions that have been documented in patients with Wilson disease. Hemolytic anemia can occur due to the damage from excess copper to red blood cells. Renal tubular acidosis can result from the impaired hepatic function and altered electrolyte balance. Likewise, nephrolithiasis may be linked to the increased excretion of certain metals and the formation of copper-containing stones.

Therefore, the absence of a connection between Wilson disease and chronic obstructive pulmonary disease makes it the condition not typically associated with this genetic disorder.