Which condition is associated with cutaneous lesions, lytic bone lesions, and hypercalcemia?

The condition that correlates with cutaneous lesions, lytic bone lesions, and hypercalcemia is most accurately associated with multiple myeloma. Patients with multiple myeloma often present with symptoms such as bone pain due to lytic lesions, signs of hypercalcemia from bone resorption, and can also exhibit various skin manifestations as a result of the underlying disease or complications.

In multiple myeloma, the proliferation of malignant plasma cells leads to the production of osteoclast-activating factors, which contribute to lytic bone lesions commonly found in the vertebrae, ribs, skull, and long bones. The release of calcium from these bones often results in hypercalcemia, which can lead to symptoms such as nausea, vomiting, confusion, and lethargy.

While other lymphomas and leukemias can present with various symptoms, including lymphadenopathy and skin lesions, the specific combination of cutaneous lesions, lytic bone lesions, and hypercalcemia is most closely linked to multiple myeloma.