Which condition involves translocation 15;17?

Translocation between chromosomes 15 and 17 is a characteristic genetic abnormality associated with Acute Promyelocytic Leukemia (APL). This specific translocation leads to the formation of the promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) fusion gene. This fusion protein disrupts normal hematopoiesis and plays a critical role in the pathogenesis of APL, causing the proliferation of promyelocytes and leading to the clinical manifestations of the disease.

In APL, the presence of this translocation is clinically significant because it aids in both the diagnosis and management of the disease. The discovery of the PML-RARA fusion gene has led to the development of targeted therapies, such as all-trans retinoic acid (ATRA) and arsenic trioxide, which are effective in treating this specific subtype of acute myeloid leukemia. The understanding of this translocation and its implications is crucial for effective patient management in APL.

Conditions like follicular lymphoma and myelodysplastic syndrome may involve other chromosomal abnormalities and mutations, but they are not associated with the 15;17 translocation typical of Acute Promyelocytic Leukemia. BTK-associated leukemia is related to mutations in the Bruton's ty