Which antibody is associated with drug-induced lupus?

Drug-induced lupus erythematosus is characterized by the presence of specific antibodies, with anti-histone antibodies being the most commonly associated with this condition. These antibodies are directed against histones, which are proteins found in cell nuclei. Their presence is indicative of drug-induced lupus, typically appearing in patients who have been exposed to certain medications such as procainamide, hydralazine, or isoniazid.

In drug-induced lupus, the clinical presentation resembles systemic lupus erythematosus (SLE), but it usually resolves after discontinuation of the offending drug. The anti-histone antibody serves as a diagnostic marker for this condition, differentiating it from other connective tissue diseases. This is why recognizing anti-histone antibodies is crucial in identifying and managing drug-induced lupus appropriately.