Which alternative treatment for gout is associated with more side effects?

Colchicine is a well-known alternative treatment for gout and is effective in reducing attacks by decreasing inflammation. However, it is also associated with a higher incidence of side effects compared to other gout treatments.

Common side effects of colchicine include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. These adverse effects can be particularly problematic as they are dose-dependent and may occur with even slight increases in dosage. As a result, while colchicine can be very effective in managing gout flare-ups, the potential for gastrointestinal-related side effects is a significant consideration in clinical practice, often influencing physician choice when deciding on treatment options.

In contrast, NSAIDs can cause side effects such as gastrointestinal irritation and increased bleeding risks, corticosteroids can lead to issues like weight gain, mood changes, and increased risk of infection, and probenecid may cause kidney stones and hypersensitivity reactions. However, the frequency and severity of side effects associated with colchicine place it in a category where caution is warranted in its use, especially regarding gastrointestinal complications.