What sign may indicate malignancy, particularly in the gastrointestinal tract?

The Leser-Trélat sign is a clinical indicator often associated with malignancy, particularly gastrointestinal cancers, such as gastric adenocarcinoma. It is characterized by the sudden eruption of multiple papules or lesions on the skin, which are typically seborrheic keratoses. This sign reflects a paraneoplastic syndrome where the underlying malignancy triggers a change in the skin, leading to the eruption of these lesions.

The significance of the Leser-Trélat sign lies in its association with the rapid increase in the number and extent of these skin lesions in the presence of an underlying malignancy. This pattern is particularly important in oncology as it may prompt further investigation into the gastrointestinal tract for possible malignancies. Recognition of this sign can guide clinicians in identifying patients who may need more extensive evaluation for cancer, especially when accompanied by other symptoms or risk factors.

Understanding the context of other related signs is valuable. For instance, Meigs' sign relates to ovarian tumors, and positive Murphy's sign is indicative of gallbladder inflammation. Cullen's sign, characterized by periumbilical echymosis, indicates intra-abdominal bleeding. While all these signs have clinical significance, the Leser-Trélat sign specifically stands out in relation to malignant processes of the gastrointestinal