What is the primary treatment for Paget disease of bone?

Paget disease of bone is characterized by abnormal and excessive bone remodeling, which can lead to pain, deformities, and an increased risk of fractures. The primary treatment for this condition involves the use of bisphosphonates, which are medications that inhibit osteoclast activity and decrease bone resorption. By reducing the rate of bone turnover, bisphosphonates help to alleviate the symptoms associated with Paget disease, such as bone pain, and they can help to stabilize or improve the bone structure, reducing the likelihood of complications.

Bisphosphonates are effective in managing the disease because they target the underlying pathological processes. They promote increased bone density and improve overall bone quality. This therapeutic approach is considered safe and provides significant benefits for patients suffering from the complications of Paget disease.

In contrast, other options such as calcitonin may provide temporary relief from pain but do not address the underlying metabolic processes of Paget disease effectively. Vitamin D supplements primarily serve to maintain calcium homeostasis and bone health, but they are not a primary treatment for Paget disease itself. Radiation therapy is not a standard treatment for Paget disease and is typically reserved for pain management in specific cases, particularly when a patient has painful bone lesions or complications from malign