What is the primary medication used for the management of an acute gout flare?

The primary medication used for the management of an acute gout flare is indomethacin, which is a nonsteroidal anti-inflammatory drug (NSAID). Indomethacin is effective in reducing inflammation and pain during an acute gout attack by inhibiting the synthesis of prostaglandins, which play a key role in the inflammatory process. NSAIDs like indomethacin are often first-line treatments because they can quickly alleviate the symptoms associated with gout flares, providing relief from the intense pain and swelling commonly experienced.

Colchicine is also used for acute gout attacks; however, its use is often limited by side effects and it is generally more effective when administered early in the course of an attack. Prednisone, a corticosteroid, can be used to manage an acute flare, particularly in patients who may not tolerate NSAIDs or colchicine, but it is not the first-line treatment. Allopurinol, on the other hand, is utilized for chronic management and urate-lowering therapy to prevent future attacks, rather than for immediate symptom relief during an acute flare.