What is the mechanism of action of clindamycin?

Clindamycin's mechanism of action involves binding to the 50S ribosomal subunit of bacterial ribosomes. This interferes with bacterial protein synthesis, which is essential for their growth and replication. By binding to this ribosomal subunit, clindamycin disrupts the translation process, preventing the formation of proteins necessary for various cellular functions. This bacteriostatic effect makes clindamycin effective against a range of gram-positive and anaerobic bacteria.

The distinction between clindamycin and other antibiotics is important. While some antibiotics inhibit cell wall synthesis or target DNA gyrase, clindamycin specifically targets the ribosomal subunit, making it quite relevant for treating infections caused by susceptible organisms. This specific mechanism highlights the role of clindamycin in treating conditions such as certain skin infections and deep tissue infections, particularly those caused by anaerobes and streptococci.