What is the likely diagnosis for endomyocardial fibrosis with eosinophilic infiltrate on cardiac biopsy?

The diagnosis of Loeffler endocarditis is characterized by endomyocardial fibrosis accompanied by eosinophilic infiltrate, particularly noted during cardiac biopsy. This condition often arises in the context of a hypersensitivity response, commonly related to exposure to parasitic infections such as Strongyloides, which leads to an increase in eosinophils.

Loeffler endocarditis presents with a distinct clinical picture, including heart failure symptoms due to restrictive cardiomyopathy, which is associated with the fibrotic changes in the heart. The eosinophilic infiltrate directly contributes to the inflammation and fibrosis observed in the cardiac tissues, leading to a fibrotic endocardium.

Other conditions mentioned do not encompass this specific combination. For example, cardiac amyloidosis involves deposits of amyloid protein, which typically does not feature significant eosinophilic infiltrates. Hypereosinophilia on its own can lead to various organ damage due to high eosinophil levels but does not specifically imply endomyocardial fibrosis. Hemochromatosis involves iron overload and does not relate to eosinophilic invasion of heart tissue.

Thus, the findings of endomyocardial fibrosis coupled with eosinophilic infiltrate on