What is indicated by a history of sinopulmonary infections, celiac disease, and anaphylaxis to blood transfusions?

A history of sinopulmonary infections, celiac disease, and anaphylaxis to blood transfusions suggests an immune system defect that is particularly linked to immunoglobulin A (IgA) levels. Individuals with selective IgA deficiency often experience recurrent infections, particularly in the respiratory tract, due to the role IgA plays in mucosal immunity. This can explain the increased susceptibility to sinopulmonary infections.

In addition, it is important to note that people with IgA deficiency may also exhibit celiac disease, as there is an association between these two conditions. The celiac disease diagnosis indicates a potentially dysregulated immune response to dietary antigens, which can occur alongside immunoglobulin deficiencies.

Anaphylaxis to blood transfusions is particularly relevant to IgA deficiency. Patients with this deficiency may develop anti-IgA antibodies, which can lead to severe allergic reactions when they are exposed to IgA through blood products. This reinforces the notion that the correct answer points towards IgA deficiency as the underlying condition responsible for the clinical presentation described.

While other immunodeficiencies like IgE deficiency, IgM deficiency, and combined immunodeficiency exist, they do not align as closely with the specific symptoms presented in this scenario, particularly the