What is a potential skin manifestation of Primary Biliary Cholangitis?

Primary Biliary Cholangitis (PBC) is an autoimmune disease characterized by the progressive destruction of small bile ducts in the liver, leading to cholestasis and liver failure. One of the notable skin manifestations associated with PBC is the development of xanthomas.

Xanthomas are cholesterol-rich deposits that typically appear as yellowish plaques on the skin, often found on the eyelids, elbows, and other areas. They arise from lipid metabolism abnormalities, which can occur as a result of cholestasis and the accumulation of lipids in the bloodstream. In individuals with PBC, the impaired bile flow contributes to elevated cholesterol levels, potentially leading to these xanthomatous lesions.

Understanding the link between PBC and xanthomas is essential for recognizing skin manifestations of liver diseases, as the presence of xanthomas can serve as a clinical clue for healthcare providers. This association highlights the importance of a comprehensive evaluation of symptoms and signs in patients with suspected liver disorders.