What is a known adverse effect of valproic acid?

Valproic acid, primarily prescribed for epilepsy and mood disorders, is associated with several adverse effects. Among these, acute pancreatitis is a significant and recognized risk. This condition can arise due to the drug's potential to induce pancreatic inflammation, which may present with symptoms such as severe abdominal pain, nausea, and vomiting.

In contrast, hemophagocytic lymphohistiocytosis is a rare and severe complication but is not a commonly known or directly linked adverse effect of valproic acid. Weight loss is generally not an effect associated with valproic acid, as the drug often leads to weight gain in many patients. Lastly, while acne can occur in various situations and with numerous medications, it is not prominently tied to valproic acid use.

Understanding these associations helps recognize the potential complications of valproic acid therapy, emphasizing the importance of monitoring patients for signs of serious gastrointestinal adverse effects like acute pancreatitis.