What condition presents with poor feeding, hypotonia, macroglossia, and umbilical hernia in a newborn?

The condition characterized by poor feeding, hypotonia, macroglossia (enlarged tongue), and umbilical hernia in a newborn is consistent with congenital hypothyroidism. This disorder is often the result of an underactive thyroid gland at birth, which leads to insufficient production of thyroid hormones. The symptoms arise due to the critical role thyroid hormones play in metabolism and development.

Poor feeding is common because infants with congenital hypothyroidism may exhibit lethargy and decreased activity levels, making them less interested in feeding. Hypotonia, or decreased muscle tone, is a direct manifestation of the metabolic slowdown caused by low thyroid hormone levels. Macroglossia can occur as part of the physical features associated with this condition, contributing to feeding difficulties. An umbilical hernia may also be associated with hypotonia, as the muscle tone is insufficient to fully support the abdominal wall.

In contrast, congenital adrenal hyperplasia typically presents with adrenal insufficiency or sexual ambiguity due to increased production of androgenic steroids, and does not commonly culminate in macroglossia or hypotonia. Down syndrome, which is characterized by a distinct set of features including intellectual disability and specific physical traits, does not typically present with umbilical hernia as a