What condition is commonly treated with St. John's wort?

St. John's wort, or Hypericum perforatum, is widely recognized for its use in the treatment of mild to moderate depression. There is substantial evidence supporting its efficacy in improving mood and alleviating symptoms associated with depression, primarily due to its active compounds that may affect neurotransmitters in the brain, such as serotonin, norepinephrine, and dopamine.

Research has indicated that St. John's wort can be as effective as standard antidepressant medications for some patients with depression, making it a popular alternative treatment option. Its use is particularly favored due to its more favorable side effect profile compared to traditional antidepressants, though it can still interact with various medications.

The other conditions listed, such as generalized anxiety disorder, schizophrenia, and obsessive-compulsive disorder, do not have the same level of evidence supporting the use of St. John's wort as either an effective or first-line treatment option. While there may be some anecdotal uses or limited studies related to anxiety or OCD, and St. John's wort is not indicated for schizophrenia, depression remains the primary and most established indication for this herbal remedy.