Marked leukocytosis, anemia, thrombocytopenia, constitutional symptoms, lymphadenopathy, hepatosplenomegaly, and bone marrow lymphocytic infiltration are indicative of which condition?

The presented symptoms of marked leukocytosis, anemia, thrombocytopenia, constitutional symptoms, lymphadenopathy, hepatosplenomegaly, and bone marrow lymphocytic infiltration are characteristic of chronic lymphocytic leukemia (CLL).

CLL is a hematological malignancy characterized primarily by the accumulation of small, mature lymphocytes in the blood, bone marrow, and lymphoid tissues. The elevated white blood cell count (leukocytosis) results from the proliferation of these abnormal lymphocytes. Anemia and thrombocytopenia arise due to the infiltration of the bone marrow by malignant cells, which disrupts normal hematopoiesis.

Constitutional symptoms such as fatigue, weight loss, and night sweats are commonly seen in various leukemias and are indicative of the systemic impact of the disease. Lymphadenopathy and hepatosplenomegaly are also common findings in CLL, reflecting the disease's effect on the lymphatic system and liver/spleen due to the proliferation of malignant lymphocytes.

In contrast to this condition, acute lymphoblastic leukemia typically presents more aggressively with blasts in the blood and bone marrow, acute myeloid leukemia is characterized by myeloid blasts instead of lymphocytes