Behcet syndrome is associated with which specific HLA type?

Behçet syndrome is closely associated with the HLA-B51 antigen. This association is significant because HLA-B51 is considered a genetic marker that increases susceptibility to the disease. Behçet syndrome is characterized by recurrent oral ulcers, genital ulcers, and ocular involvement, among other symptoms. The presence of HLA-B51 is observed more frequently in individuals with Behçet syndrome compared to the general population, indicating a potential role of the immune system in the pathogenesis of the condition.

In the context of HLA types, certain antigens like HLA-B51 have been studied extensively for their connection to autoimmune and inflammatory disorders. The knowledge of specific HLA associations helps in understanding the genetic predisposition and guiding clinicians in diagnosis and management, particularly in populations where the prevalence of Behçet syndrome is high.

The other HLA types listed do not have a similar established association with Behçet syndrome. While HLA-DR4 is linked to rheumatoid arthritis, HLA-A2 has been associated with multiple autoimmune diseases but not specifically with Behçet syndrome. HLA-Cw6 is commonly associated with psoriasis rather than Behçet syndrome. Therefore, the identification of HLA-B51 as the specific antigen associated with Behçet syndrome